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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a6d1a0cd9d22f7c5eb1a347a9677a3f541c67635f4ccd7fa2257bf60f7562169' 
  AND token = 'IgS857KeGjYAL+ugBLWyyAxs07SfJaYu5KtLyQBXSqY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}