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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'aea46aad04147725903d80a6f292b21f0f2f25fecf4b3dd3e7fd60640449fc29' 
  AND token = 'w3Mt7Js5VRSUNPKeognMmgT13XZotCqPlf/3brK9ecw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}