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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'cafd4d6a68b5869a2799f23dbf052d4dcf6cfbb326f04bd6d90797c243242340' 
  AND token = 'hF39pOjyemDYUMSUVvUGZ3mYW0FTDSgMX3pLhV9w9O0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00015

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}