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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ce15288df21952e8e3f892d1227215ff6c283e3d25a02e680c90651202bb0e3c' 
  AND token = 'SyNF+dzlw261nb/PmaDxk+IfxnvzzJqQ7K8+RtnFucQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}