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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '41b4429bf2e022fa5e2baf582ceddf99eb0e60dcd0dd8319cb3b730b8e4b3c54' 
  AND token = 'R2A2LbcIShLUT01mZLVgqEDq+Vz7B1xF4tUxSCS3AsQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}