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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '880518f1b155c2269035573b9f4af3a3296a8842d3e0714d1f55f0a4468ba37f' 
  AND token = 'sV8Ft1wmQnrp93hakFXvl4Mk+Z90mGcvUfuWUoMwvvU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}