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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e91a22009e825af737ab9e4784ef54426ce02e028c8cb06a4047bcc218a4eca1' 
  AND token = '0YT3iLyxDR2MRPmRyuR21tgp+V3mlM8VPMhRs4KJxoU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}