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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b37737ca6fbc6a66c9e00e6d58289301154deee2934ab3c0c72fe1cde3da0755' 
  AND token = 'L+So6iZrDy7IG7gmNnjhMOfNlLHX0aLQsejpYdZLW7E=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}