SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e42889839fc32a00a6c5d6c693363d16a5bf9f8535b860944b19e6719561f312' 
  AND token = 'RCpKdX1oN1pxBAjonCua4LblRLTu2SXKHD8ZAkYy4lA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}