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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '49f9a03abd662435c5ef31d8ac398654088ed3282c6bbba04ad5ff2ecacdcb1d' 
  AND token = 'RpkD0mZii6L21cbk7IjMjKUO3nFZApN3vhgZIN7BUjM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}