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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0d69d878a2c42dda4c32e048fb47f6a411abdac00b487b39046750d8f0da8af1' 
  AND token = 'Uj0F3oBwOwbWeFmY/ch1X3u9scCY+bIIsZKHg5XpXkU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}