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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2a0051d273f8c70378fd4d20e9f864461b58ad9b8cff945e887b24004041fa26' 
  AND token = 'khqUme0P/QW30MPIWG3n/lWc2RTdGCDMSzpmeOZbFX8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}