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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e7ca99d17d8c9cc2e1452fc0a72494e16699c2ddde2104610689d3590a643d1b' 
  AND token = 'Lnm9MoaxwOUbvnGm2QnaSKzb0ItnCx5mFMZP2RVHOes=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}