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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f2f733fa9bf5fdfecc7df54a963797fe821387644b6048ba78802f3388a47805' 
  AND token = 'UqH+6rMCD20IA4bDz+TeXHJEFqc/bMQao6bBQnSgBd4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}