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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b00a25f40a5b6f03596a42775427c1970b4c80d9b17b1977c837a07e4bd456a0' 
  AND token = 'hRg3Gs3f59HUMk3Bckm6LW2T9R8ZVCkvvMBpyr7gcuA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00055

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}