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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f345c8ec35c9c26b539b8de9c758cdfb2ee283344712a80cfe9b847e9433e2af' 
  AND token = 'gIHsHRtcQ4CGuqOkbNtshPj6JUONaxYdWe7OCYuDmzw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}