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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a1cff533517e7b7fa93f7f80802248182019a56bdf24c14c47505fc84c37429b' 
  AND token = 'pV0nXwkA97a8+JhfRlUP5gbFMweP6G+5ZS3XDiXQaAY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00015

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}