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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '43c5b75fd0572d9916fdf45c9e6cbf155249879e95e9e2c32129ab00fb5855bc' 
  AND token = '++KIofCUXHqfU2g9vwIfwtVUGCojTRVTA1ZepWEQzeI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}