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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '40eb8c10a7c26e2a494370e4834e2701fe0e8ba5908c6256a5139068023f39f1' 
  AND token = 'kW4Nk9xNqF7JceRjnM3u8+t7XLbqVuv0Drm3X36dkpI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}