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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '53f125d8a905331c35add2a87236c3b08cf33b6692b1297b66611c686ad401dc' 
  AND token = '6+VDX64G7n5CbNrXM7riYnLdKrHKn2xTN88k7RxU62g=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}