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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c5bdc4c7fc9aa51c41d970c9a239019fc70891bd92358e72e9f4a096a4991459' 
  AND token = 'xUfNodKVEOpiSjagFVAFzOqF0eaQDxO5doNjKuaCVpg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}