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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '53ed624c114c7e90d800fa6f04f9d27f04bcda637830e3a32da86de9f3086c90' 
  AND token = 'TloPXDdmBv2betVxn7v4j6777HpOonmstz7+4Fg4pzI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}