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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4286f80bbb238d2f024fe24f687ce3ad0af7072700cf9cc1913f0a4505fbcaf8' 
  AND token = 'eOFE5w8I2aJhy5f1EMrrnYqznui6Z1cDfmKXgETWIpg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}