SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'eb50f559be79c0cbdfa7599e0cef1bb9c2146b6851b325e34d5e4dc3f86c7f67' 
  AND token = 'csTY+aVSjpx+u+Yc2iyisa48JUKNdHhnPK0AtDzg6y0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}