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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8ee00d7cc83281bf9e45a95397011b34468849470051f0d11f8bb9678ee6a72f' 
  AND token = 'RynO6gfY/NY+h4AUdwkiObzlDS45YEPOV+uDhpm4hCg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00031

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}