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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '7450ed099728c0cdb03db8a19b7201a0e968d305698aae0b0197558208ca1ed9' 
  AND token = '727NuwG4dnASrPgFgAlfEGuTwPlgRhb0yoaVaY98Vzk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00055

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}