SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '21efb8bbe215fc140e7b0fb7b50741ad855f8e727b666694f12fc670716bba4d' 
  AND token = 'mNQmMyufrgSwRLV12kdBmRXdt/PVx/5U1ziCM/8n9KI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}