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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5bdd7d9bdf33bbfb860a25d78da8ca946e97f7a36a4738d3404b1b392f6da805' 
  AND token = '8N3LD6JemAWubND2KeRzIayIr5bZX4a3hsSVE4efXjQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}