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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '41b6e41e377c9ab0f26ffea8242f271d71a1c2d1ea1c7ba81cd846ffd28e0764' 
  AND token = '8rBAHQpfEcYdkVDqLQdcAQsmOYAL5RVTjKMEmr9Kzic=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}