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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '41b29888cecf6a23f9cb3f349d6450866ad6cbf67faa9934e15f50e7a76c1f22' 
  AND token = '8hSEN2/yboWkf9PZ131Vdwwmc4WeIUtJAB/r+9kTTLM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00015

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}