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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'edada4b5e6e7049d44f9de7f30c36b87c09d58b2c6da4220bc6b3720e81629ab' 
  AND token = 'tkDh3Oi00TlvRumUjK5kXGE/A3q8uJDhFaA3IOZaRE8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00016

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}