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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '7c63093edbf78f33c5e4954e2c7c5a499900b5df41192e0f7c2351cf4f1bcfae' 
  AND token = '6xMDv1u4u2G0OYD2nCd6zPWO3lQGA9oFKCJ+3ob2zps=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}