SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '65af05834f2c7cf5aa80c5e7042859ae49ec16f620b217a8f116c1cf40145682' 
  AND token = '35BpthutbyHyGXDogxPvj2s/dR2jV0gF5krChxIV2n4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}