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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5e1e9fdd9c4a153e19b9f9b408d1ec519b1255f2f392baa25238f08d3b939e80' 
  AND token = 'X7TrU0/B3oPtGxgQ3EGy11p1nnCi3siW0BP7A9+3r54=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00014

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}