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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4693105f3730b1c66596a8fe593208324100fa2181c31f41538211ad83edde2c' 
  AND token = 'I2K20Ag2G8NM9K8ugdsvt21zftlp53z9RpJIFzarGdw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}