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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c854c1212ce377c1be63cacf567fb7785cc2ecbf0a80e485d7d27449ed0ccf49' 
  AND token = '0/cgqRlI8dlySs48imC+aV7DKEiAXCtCnMCOeLueKUg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}