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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '48221995b361ad1b160e3992d14d003fa11dcd9212f7fe262547f7ef6d0be92e' 
  AND token = 'TJZWw6ReHBPDNSTKoqWUp+46uYx3np/zaXyp9pptbLA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}