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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'de309a75fd7f2ce1caf2f7686b4011d491279b29554fb0bf9710fb87c0f3aad3' 
  AND token = 'y0qx07qvgeFo9k/9YRZxYf0QOzMWtl1AdxWn6BTjVtg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}