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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f59a105505d727a16a78cdce332f26d5597f1b72fbb1505398b4b40ff62227a4' 
  AND token = 'M7WWyTKUJjcNt8PtU+tfpqs0TuWmitR+alSeN8PM+Ro=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}