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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '452dc39db2f6f0c2b263f2e73c2a48ced8ab93a72555350861fbd72c06825214' 
  AND token = '1Y86eSTrTAi5M2I2gXjsD29NDjPJpd8hXCW6ca5Ab9Y=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}