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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '650db9025bf406388a0b6d13d0b19081f3704950d0a51ae7b260317404b1c903' 
  AND token = 't3gS9bDIwpM8JJ8DyJ3WfKZNCo+5Nxj09TFzMISo7vY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}