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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5d9fd4b318827b2950806ca27b65b2f80a4473fa435e55fa54da1d8f45b5c2a0' 
  AND token = 'VpZ1eCrdOoU+Qgbk2r26oNz2vh++yc/o1PHzeMmVyvE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}