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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'be7fd20c781e195e96e94e1fb9205bf73c49e390c38e266c0e7b6e6a558d6859' 
  AND token = '/Y4Q4xNb0NaFEkW9u/KoWwlMjT5+xEkpgJOKbSGF1s0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}