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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22ec815aacf55c799682cbd7e39063d73ccb0c5d138ece4d4c44b3f465505703' 
  AND token = 'z6bg/iAt9US4wjgpNF2aolBbugcHuIehBzwzIzV/LGA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}