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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5c117b50cad6c44b08076642df28eba1ae42ad4b85dc25fa09c2d69977bf459a' 
  AND token = 'TP3MJlDD/7im/HTHOY0lHK/WtHKboyEK3iAs+8UaQnE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}