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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '161cde85aaa844da4eace2927c65695542fd3fa685e2ca0ee6658bb0b8789496' 
  AND token = 'FhySQU3YlSlP/nCCcYmhbU/HUA+auoMINe9WV4P2u6Y=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}