SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c95e33ed99ab04f42b2a5de5cbfd68e55a90f6785d06d16018658f13e64c44b5' 
  AND token = '6EOVJd85dE/jXGARQjtT0txX3UMbVTz4gsWkjwlrqLE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}