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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a53dcccc63be8685adfd6be82b0deb7735b8721f0089a86686697f4290355aca' 
  AND token = 'G53QWEKEaedVkOptgNUpmQwRlH3yc7WZQkboJ4LPrqM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}