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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c0e8b257f4fb28793580e72fd90b4648c17287b90a2c84aa021f3bd2f5c21906' 
  AND token = 'yTeX3rHCwkppgebDQIZVm6NxUcMurSXSlv//hPE5k8w=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}