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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '218f53e439c8c1fc5059667eba9eb19dcfead589c0f2d031b823d266b3649689' 
  AND token = 'LB6e9n3na3Vzs2cDtSoELoONOL2/yARnu3mxHw9NLWU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}